Archive | Biotechnology

Ultrasonic with Low-Foam Detergent

Q. We are having foaming issues in ultrasonic cleaner. Basically, we are looking for a non-foaming version of the Liquinox cleaner we are currently using.  Can you use a detergent that doesn’t foam in an ultrasonic bath? A. Depending on what the foaming issue is, you may be able to continue using Liquinox detergent. As a general statement….

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Posted in Biotechnology, Healthcare, Laboratory, Liquinox, Manual Lab Cleaning, Medical Device, Pharmaceutical, Solujet0 Comments

Detonox 1 gallon

What is Detonox detergent?

Q: You recently recommended Detonox detergent for a tough cleaning challenge we had. You rushed a sample over and it worked fantastically. I have review your technical bulletin, but is there anything else you can tell me about it? Is it better than Alconox and Liquinox? It seems great.

A: Thank you for the feedback and question…..

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Posted in Biotechnology, Cosmetic, Detonox, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments

Monitoring Bath Life Extension in Medical Device Cleaning

Q. What is the best way to monitor for bath life extension?
A.To avoid potential for cross contamination, only freshly made up cleaning solutions should be used for the highest levels of critical cleaning. In general, a pH change of 1 unit towards neutral indicates an exhausted cleaning solution. Bath life can be extended. Learn How.

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Posted in Biotechnology, Cosmetic, Healthcare, Laboratory, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments

Continuous processing protein

Alconox, Inc. Detergents and Continuous Bioprocessing

Q. How can Alconox detergents assist with our movement to continuous bioprocessing? A: Continuous bioprocessing is an exciting newcomer to the biotech realm. It has been used in industries such as food and chemicals for some time, effectively so. With improvements in cell culture perfusion, and the many forms of disposable technologies on the market, footprints can be reduced making continuous processing for biotech products a reality for many applications.

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Posted in Biotechnology, Citrajet, Detonox, Filter, Liquinox, Solujet, Tergazyme0 Comments

Risk Based Limits and Pharmaceutical Cleaning

Q. We are moving from LD50 data to ADE (PDE) limits based on HBELs. This is allowing us to eliminate disposables for low-risk products.  How do I know which can be manually cleaned and which needs to be in a washer? Can manual cleaning be validated?

A. Many pharma and biotech companies have been moving to Health-Based Exposure Limits (HBELs) meaning Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) limits as detergent residue limits.    

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Posted in Biotechnology, Pharmaceutical, Validation0 Comments

Solution Preparation Tank

Cleaning Titanium Dioxide from Tanks

Residual titanium dioxide (TiO2) can certainly pose issues due to it’s nature in the presence of heat. To remove TiO2 from tanks using CIP sprayballs, it is important to use….

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Posted in Biotechnology, Cosmetic, Keylajet, Pharmaceutical, Solujet0 Comments

Defining Free Rinsing Detergent

A non-free rinsing cleaner might contain fragrances that were designed to deposit and leave a fresh scent, or it might contain corrosion inhibitors that are designed to deposit and leave behind an anti-corrosion film.

Alconox, Inc, cleaners are free rinsing detergents and do not leave deposits on substrates after rinsing.

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Posted in Aerospace, Alcojet, Alconox, Alcotabs, Biotechnology, Citrajet, Citranox, Cosmetic, Detergent 8, Detergents, Detojet, Electronic, Environmental, Filter, Food & Beverage, Foodservice, Healthcare, Laboratory, Liquinox, Luminox, Medical Device, Metalworking & Precision Manufacturing, Nuclear, Optical, Pharmaceutical, Photovoltaic, Solujet, Tattoo, Tergajet, Tergazyme0 Comments

Biocompatibility Testing for Pyrogens

Your detergents have corresponding biocompatibility data. Our medical devices must be pyrogen and endotoxin free. Someone mentioned that biocompatibility tested detergents, like yours, will be free of organic residues like endotoxins and pyrogens. Is this true?

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Posted in Biotechnology, Medical Device, Pharmaceutical0 Comments

Pharmaceutical Cleaning: Probiotics

Q: Can you tell me if Liquinox can clean/remove pharmaceutical probiotics? We use this product to clean our packaging lines. We have a customer who is looking to have us package their probiotic product.

A: Liquinox® Critical Cleaning Liquid Detergent is an excellent emulsifier of organic and oily residues. It will do the job. Best practice, however, would be to incorporate a powerful emulsifier of organic and oily residues, along with enhanced protein removal. 

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Posted in Biotechnology, Liquinox, Pharmaceutical, Tergazyme0 Comments

closed bioprocessing

Closed Bioprocessing Cleaning Recommendations

Q: We are a mid sized small biomolecule drug manufacturer and currently use several Alconox, Inc. products in our cleanroom and manufacturing suites.  We are looking at implement (functionally) closed bioprocessing.  Are there any recommendations you can provide?
A: Some time ago, I heard a senior executive of a large biotech company express a desire to produce drugs in a “conference room.”  That day is pretty much here. 

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Posted in Biotechnology, Pharmaceutical0 Comments