Archive | Biotechnology

Residue Detection: Swab Method

Q. Do you have a recommended swab detection method for residual detergent?

A. We most certainly do.  It is suggested to use a swabbing area of 5 cm X 5 cm. Where extreme low level acceptance criteria on a low recovery residue, i.e. some product residues, it can help to….

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Posted in Biotechnology, Detergents, Laboratory, Medical Device, Pharmaceutical, Validation0 Comments

3D

How to: Clean 3D Printed Parts

Q. We need to clean 3D printed plastic parts made of methacrylate. We need to make sure it’s safe for the plastic, but also ensures all crevices are residue free for critically clean parts.

A. Particulates and other residue, including environmental residues, can be effectively cleaned using a….

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Posted in Aerospace, Biotechnology, Electronic, Healthcare, Liquinox, Manual Lab Cleaning, Medical Device, Metalworking & Precision Manufacturing, Ultrasonic0 Comments

How to Clean Labware: Removing Algae

Q. We are a large energy company working with algae.  It is proving tough to remove from glass and labware. We are using Liquinox detergent currently, which is good.  Anything better? Eventually we would like to move to cleaning these in our washer.

A. Algae, and the viscous oils that you are working with, require not just powerful emulsifiers….

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Posted in Alcojet, Biotechnology, Detojet, Environmental, Laboratory, Liquinox, Tergazyme0 Comments

Bathocard

9 Steps to Successful Critical Cleaning: BATHOCARD

Q. Did you know there are nine different factors that determine successful cleaning? A. “BATHOCARD” a phrase coined by Alconox technical team.

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Posted in Biotechnology, Cosmetic, Detergents, Food & Beverage, Healthcare, Industry, Laboratory, Medical Device, Metalworking & Precision Manufacturing, Pharmaceutical, PhotovoltaicComments Off on 9 Steps to Successful Critical Cleaning: BATHOCARD

TFF Cassette Cleaning

Q. We use Tergazyme to clean our TFF cassettes and it’s working well. However, we are moving to CIP cleaning in an automated, high pressure environment and are worried about foaming. Do we stick with Tergazyme or is there a better detergent we should use?

A. Tergazyme® Enzyme-Active Powdered Detergent is of an excellent choice for cleaning TFF cassettes. Even as you move to more high pressure, automated CIP method, Tergazyme detergent will likely continue to work well. That’s because….

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Posted in Biotechnology, Detojet, Tergazyme0 Comments

Ultrasonic with Low-Foam Detergent

Q. We are having foaming issues in ultrasonic cleaner. Basically, we are looking for a non-foaming version of the Liquinox cleaner we are currently using.  Can you use a detergent that doesn’t foam in an ultrasonic bath? A. Depending on what the foaming issue is, you may be able to continue using Liquinox detergent. As a general statement….

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Posted in Biotechnology, Healthcare, Laboratory, Liquinox, Manual Lab Cleaning, Medical Device, Pharmaceutical, Solujet0 Comments

Detonox 1 gallon

What is Detonox detergent?

Q: You recently recommended Detonox detergent for a tough cleaning challenge we had. You rushed a sample over and it worked fantastically. I have review your technical bulletin, but is there anything else you can tell me about it? Is it better than Alconox and Liquinox? It seems great.

A: Thank you for the feedback and question…..

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Posted in Biotechnology, Cosmetic, Detonox, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments

Monitoring Bath Life Extension in Medical Device Cleaning

Q. What is the best way to monitor for bath life extension?
A.To avoid potential for cross contamination, only freshly made up cleaning solutions should be used for the highest levels of critical cleaning. In general, a pH change of 1 unit towards neutral indicates an exhausted cleaning solution. Bath life can be extended. Learn How.

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Posted in Biotechnology, Cosmetic, Healthcare, Laboratory, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments

Continuous processing protein

Alconox, Inc. Detergents and Continuous Bioprocessing

Q. How can Alconox detergents assist with our movement to continuous bioprocessing? A: Continuous bioprocessing is an exciting newcomer to the biotech realm. It has been used in industries such as food and chemicals for some time, effectively so. With improvements in cell culture perfusion, and the many forms of disposable technologies on the market, footprints can be reduced making continuous processing for biotech products a reality for many applications.

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Posted in Biotechnology, Citrajet, Detonox, Filter, Liquinox, Solujet, Tergazyme0 Comments

Risk Based Limits and Pharmaceutical Cleaning

Q. We are moving from LD50 data to ADE (PDE) limits based on HBELs. This is allowing us to eliminate disposables for low-risk products.  How do I know which can be manually cleaned and which needs to be in a washer? Can manual cleaning be validated?

A. Many pharma and biotech companies have been moving to Health-Based Exposure Limits (HBELs) meaning Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) limits as detergent residue limits.    

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Posted in Biotechnology, Pharmaceutical, Validation0 Comments