TechNotes

Q: We understand from your literature, that pre-soaking in a solution prior to washing is a good idea.  We are washing pipettes in a syphon washer using your Alcotabs.  Can we create an Alcotabs solution for the pre-soak?  A 1%?  How many tablets? A: Thanks for the inquiry.  Often times, a minor re-purpose of an […]

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Q:  You recently sent a sample of Tergazyme detergent for a tough cleaning challenge and it worked better than anything we had previously tried. I realize this must be due to the enzyme component. What information can you provide me on how enzyme detergents work, so I can share it with our decision makers / executives who want to better understand why this detergent got such different results?

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Q. It appears that the Solujet is leaving a ring on some of the labware that cannot be removed. What is this ring (sodium silicate?)? How do we remove it? The labware has not been completely submerged. We have just added the Solujet soak for some labware that may have stubborn organics. We have been giving the labware a 4 hour soak in 1% Solujet, followed by warm tap water rinse then wash with Liquinox followed by 3x DI rinse.

Click for the Answer.

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Q. We have glassware that contains adhesive and API dissolved in organic solvents. If we do not do additional organic rinses prior to the aqueous rinses we have issues. Is there any way we can avoid the organic rinses?
A. To avoid organic rinses, you can soak in a high emulsifying cleaner such as a 1% Alconox solution (1.25 oz/gal or 10 g/L) prior to aqueous rinsing. Ideally soak in a warm or hot solution for fastest and most reliable results. The emulsifiers in Alconox will emulsify the solvents and active pharmaceutical ingredients (API). Be sure to rinse at the same temperature you are soaking at so you do not break the emulsion and redeposit the API or solvents. If you soak hot . . .

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My question is related to a minimum detergent concentration.  We manually wash labware of all sizes in 0.3% Liquinox solution. We also pre-wash or pre-rinse the labware and control our parts load.  We rarely have failures. We want to change our protocol to extend the wash water use for one day instead of based on a numerical parts load.  Do you think a 0.3% Liquinox concentration is sufficient detergent capacity to go an entire day?

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Q. How can I clean proteins, RNA, and DNA from laboratory equipment?

A. Thank you for your question concerning cleaning proteins, RNA and DNA from laboratory equipment.

We will address each separately . . .

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Q: We are a large biotech and in an effort to go green with our cleaning, we are exploring cold cleaning (cleaning with cold water) using your detergents. A: Cold cleaning is a very reasonable approach for energy conservation, and in short, its effectiveness depends on the details of the application.

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We are in the process of building a cleanroom for medical device manufacturing. What detergents do you recommend? For cleanroom cleaning, we would recommend liquid concentrate detergents to…..

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Q. We are looking for a product that will allow us to clean mold release agent from the surface of molded HDPE parts. A. The best way to reliably remove silicone based mold release agents is to immerse the HDPE parts in very hot (170ºF) 2% Alconox detergent followed by a very hot (170ºF) rinse, ideally both in ultrasonic tanks. After the first very hot rinse, normal ambient temperature rinsing can be done. This can also be done with stiff brushes, but of course protective equipment must be worn.

The theory behind this is that …

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What is the difference between Tergazyme and Alconox? Is one better? Is one more mild?

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