Archive | Pharmaceutical

Ensuring Accurate Formulation of Liquinox Detergent

Q. I am a validation manager and we use Liquinox in multiple pieces of equipment across our manufacturing site. While witnessing our cleaning, I noticed the dilution instructions are not being followed. Instead, operators are adding some squirts/pumps/pours from the bottle into a bucket with purified water. Does Liquinox have a range of effective concentration?  Do you have auto-mix ideas or other dosing solutions for customers facing this issue of accurate formulation?

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Posted in Biotechnology, Cosmetic, Liquinox, Medical Device, Pharmaceutical0 Comments

Do Enzymatic Detergents, Like Tergazyme Cleaner, Disinfect?

Q. I’m a Ph.D. student and I’m studying protein interactions. We have been using Tergazyme to clean lenses and cuvettes for our light scattering equipment and it works flawlessly! My question is: Does Tergazyme enzyme detergent have any disinfection properties, like killing of bacteria such as E. coli?

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Posted in Food & Beverage, Laboratory, Medical Device, Pharmaceutical, Tergazyme0 Comments

Water Spots on Stainless? Improve Blowing Process

Q. White spots appear on our stainless steel parts the day after cleaning with Alconox. Right after we clean them, they are dry and visually clean. So, is this next-day residue from the Alconox detergent? If not, can you tell us why this is happening? A. It is fairly unlikely that visually clean parts have Alconox residues suddenly appearing the next day.  In addition to Alconox being free rinsing, any residue that did not get rinsed for whatever reason, would be visible fairly immediately.

Most people in similar situations, even though the parts appear “dry and visually clean,” find that the spots are from water.

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Posted in Alconox, Biotechnology, Foodservice, Healthcare, Laboratory, Manual Lab Cleaning, Medical Device, Metalworking & Precision Manufacturing, Pharmaceutical0 Comments

How Does Tergazyme Enzyme Detergent Work?

Q:  You recently sent a sample of Tergazyme detergent for a tough cleaning challenge and it worked better than anything we had previously tried. I realize this must be due to the enzyme component. What information can you provide me on how enzyme detergents work, so I can share it with our decision makers / executives who want to better understand why this detergent got such different results?

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Posted in Biotechnology, Foodservice, Healthcare, Laboratory, Manual Lab Cleaning, Medical Device, Pharmaceutical, Tattoo, Tergazyme0 Comments

Cleaning Vape Cartridge Manufacturing Equipment

We are manufacturing vape cartridges and are removing residues of viscous resins, essential oils, glycerin and flavor enhancers with a CIP system. Some of these are botanical heavy resins and waxy. Can Alconox, Inc. help? Learn more…

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Posted in Keylajet, Pharmaceutical, Solujet0 Comments

Removing Protein in Pharmaceutical and Biotech Manufacturing

Q. How do you remove protein out of pipes, centrifuges and tanks in a CIP environment with water temperatures averaging 20C?

A. In a cooler temperature environment, consider adding an enzymatic cleaner to your alkaline/acidic CIP routine. A product like Tergazyme® Enzyme-Active Powdered Detergent, which contains both protease and surfactants, is not only efficient at removing the biofilm, but will also slow down the formation of biofilm and allow the regular cleaning cycle to clean effectively for more cycles.

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Posted in Biotechnology, Pharmaceutical, Tergazyme0 Comments

Clean-in-place (CIP) with Citrajet Detergent

Q. Our pharmaceutical company is transferring product manufacture to a different one our facilities. We used a CIP cleaning process with Citrajet and are going to have to perform validation and verification tests again. What information do we need for our testing? Chemical properties might be helpful as well as the science on how this chemical works. We would also need information on disposal and the requirements for allowing this to flow to normal process drains.

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Posted in Citrajet, Keylajet, Pharmaceutical, Solujet, Validation0 Comments

Cold Cleaning

Q: We are a large biotech and in an effort to go green with our cleaning, we are exploring cold cleaning (cleaning with cold water) using your detergents. A: Cold cleaning is a very reasonable approach for energy conservation, and in short, its effectiveness depends on the details of the application.

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Posted in Biotechnology, Cosmetic, Laboratory, Manual Lab Cleaning, Medical Device, Metalworking & Precision Manufacturing, Pharmaceutical0 Comments

BRK Cleanroom

Cleanroom Cleaning

We are in the process of building a cleanroom for medical device manufacturing. What detergents do you recommend? For cleanroom cleaning, we would recommend liquid concentrate detergents to…..

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Posted in Biotechnology, Liquinox, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments

Cleaning Stressed Polycarbonate

Q. In the past you have recommended a specific detergent type detergent for our sensitive plastics (stressed polycarbonate), mentioning that it does not have a surfactant. Can you elaborate for us why?

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Posted in Biotechnology, Cosmetic, Detojet, Medical Device, Pharmaceutical0 Comments