Archive | Pharmaceutical

Pharmaceutical Cleaning: Choosing CIP Detergent  

Equipment used in pharmaceutical manufacturing must be cleaned before each use, and the cleaning procedure used must be in accordance with good manufacturing practices (GMPs). There are different types of CIP including, single pass systems and recirculation system. No matter which type is used, Alconox, Inc. provides support to meet cGMP regulations and detergents ideally suited for CIP systems.

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Posted in Citrajet, Pharmaceutical, Solujet0 Comments

Visit Us at Pack Expo 2018 with Comped Admission

Visit Alconox, Inc. at PACK EXPO International and Healthcare Packaging EXPO 2018, at McCormick Place in Chicago, October 14-17, 2018.  Mention Code: 72W43 for free registration to the event. 

Once at the show, stop by Booth W-803 to receive our unique gifts, expert technical support for your critical cleaning applications, and detergent samples.

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Posted in News, Pharmaceutical0 Comments

Using High Foam Detergent in an Automated Ultrasonic Cleaning Line

Q. Can we use high-foaming detergents in an automated cleaning line?
A. Yes, but using a high-foam detergent requires a rinse chamber that allows foam to rinse off and drain easily and completely. If the automated line uses initial spray rinsing right after the wash tank

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Posted in Citranox, Cosmetic, Liquinox, Medical Device, Pharmaceutical0 Comments

Risk Based Limits and Pharmaceutical Cleaning

Q. We are moving from LD50 data to ADE (PDE) limits based on HBELs. This is allowing us to eliminate disposables for low-risk products.  How do I know which can be manually cleaned and which needs to be in a washer? Can manual cleaning be validated?

A. Many pharma and biotech companies have been moving to Health-Based Exposure Limits (HBELs) meaning Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) limits as detergent residue limits.    

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Posted in Biotechnology, Pharmaceutical, Validation0 Comments

Alconox Liquinox

Differences between Alconox and Liquinox

Q. Currently using Alconox, but are considering a switch to liquinox. We have seen less residuals with Liquinox, which is desireable. What are the recommendations and concerns with switching from Alconox to Liquinox? What are the difference in ingredients between the two?
A. Alconox and Liquinox are functionally equivalent cleaners, but are not chemically identical. Click to learn more and access the Liquinox and Alconox msds.

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Posted in Alconox, Ask Alconox, Laboratory, Liquinox, Manual Lab Cleaning, Medical Device, Pharmaceutical, Validation0 Comments

Biocompatibility Testing for Pyrogens

Your detergents have corresponding biocompatibility data. Our medical devices must be pyrogen and endotoxin free. Someone mentioned that biocompatibility tested detergents, like yours, will be free of organic residues like endotoxins and pyrogens. Is this true?

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Posted in Biotechnology, Medical Device, Pharmaceutical0 Comments

Manual Cleaning A 100 Gallon Mixer

Q: We are looking for detergent and process recommendations for manual cleaning of a 100 gallon mixer. We make one product in the mixer which contains water, modified food starch, acidic buffers, sucralose and preservative. Currently when cleaning, we boil for 1 hour at 90°C, then cool, drain and soak in cool water while using the mixing blades.  Scrub brushes and a spray hosing follows that. The mixer is made from stainless steel.

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Posted in Alconox, Citranox, Liquinox, Pharmaceutical2 Comments

Cleaning Pharmaceutical Probiotics

Q: Can you tell me if Liquinox can clean/remove pharmaceutical probiotics? We use this product to clean our packaging lines. We have a customer who is looking to have us package their probiotic product.

A: Liquinox® Critical Cleaning Liquid Detergent is an excellent emulsifier of organic and oily residues. It will do the job. Best practice, however, would be to incorporate a powerful emulsifier of organic and oily residues, along with enhanced protein removal. 

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Posted in Biotechnology, Liquinox, Pharmaceutical, Tergazyme0 Comments

closed bioprocessing

Closed Bioprocessing Cleaning Recommendations

Q: We are a mid sized small biomolecule drug manufacturer and currently use several Alconox, Inc. products in our cleanroom and manufacturing suites.  We are looking at implement (functionally) closed bioprocessing.  Are there any recommendations you can provide?
A: Some time ago, I heard a senior executive of a large biotech company express a desire to produce drugs in a “conference room.”  That day is pretty much here. 

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Posted in Biotechnology, Pharmaceutical0 Comments

Cleaning a Dry Powder V-Mixer

We are cleaning a V Mixer made of NSF Stainless steel and we are using it to mix different protein powders, amino acids, and herbs for dietary supplements. It is small enough to be cleaned by hand but not small enough for any type of sink. I was advised to buy your Citranox product. Is that the best detergent for this job?  

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Posted in Citranox, Pharmaceutical, Tergazyme0 Comments