Archive | Pharmaceutical

Cleaning Botanical Residue in Manufacturing

Q: We are manufacturing cannabis products, legally, in California, but are struggling with cleaning cannabis residue. We cannot find any current Good Manufacturing Practice (cGMP) documentation to help us. Can you help us?

Read the full story

Posted in Ask Alconox, Cosmetic, Detonox, Healthcare, Keylajet, Laboratory, Pharmaceutical0 Comments

Pharmaceutical Cleaning: Choosing CIP Detergent  

Equipment used in pharmaceutical manufacturing must be cleaned before each use, and the cleaning procedure used must be in accordance with good manufacturing practices (GMPs). There are different types of CIP including, single pass systems and recirculation system. No matter which type is used, Alconox, Inc. provides support to meet cGMP regulations and detergents ideally suited for CIP systems.

Read the full story

Posted in Citrajet, Pharmaceutical, Solujet0 Comments

Visit Us at Pack Expo 2018 with Comped Admission

Visit Alconox, Inc. at PACK EXPO International and Healthcare Packaging EXPO 2018, at McCormick Place in Chicago, October 14-17, 2018.  Mention Code: 72W43 for free registration to the event. 

Once at the show, stop by Booth W-803 to receive our unique gifts, expert technical support for your critical cleaning applications, and detergent samples.

Read the full story

Posted in News, Pharmaceutical0 Comments

Using High Foam Detergent in an Automated Ultrasonic Cleaning Line

Q. Can we use high-foaming detergents in an automated cleaning line?
A. Yes, but using a high-foam detergent requires a rinse chamber that allows foam to rinse off and drain easily and completely. If the automated line uses initial spray rinsing right after the wash tank

Read the full story

Posted in Citranox, Cosmetic, Liquinox, Medical Device, Pharmaceutical0 Comments

Silicon Oil

Cleaning Silicone Grease Residue Build Up in a Parts Washer

Q. Our parts washer uses a 2.5 hour cycle following a manual wash. A build up of silicone grease is observed. Our preference is to reduce manual cleaning. Is there a cleaning agent available that can remove silicone grease that would be compatible with a parts washer using water as the cleaning agent?

Read the full story

Posted in Alcojet, Medical Device, Pharmaceutical, Solujet0 Comments

Risk Based Limits and Pharmaceutical Cleaning

Q. We are moving from LD50 data to ADE (PDE) limits based on HBELs. This is allowing us to eliminate disposables for low-risk products.  How do I know which can be manually cleaned and which needs to be in a washer? Can manual cleaning be validated?

A. Many pharma and biotech companies have been moving to Health-Based Exposure Limits (HBELs) meaning Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) limits as detergent residue limits.    

Read the full story

Posted in Biotechnology, Pharmaceutical, Validation0 Comments

Alconox Liquinox

Differences between Alconox and Liquinox

Q. Currently using Alconox, but are considering a switch to liquinox. We have seen less residuals with Liquinox, which is desireable. What are the recommendations and concerns with switching from Alconox to Liquinox? What are the difference in ingredients between the two?
A. Alconox and Liquinox are functionally equivalent cleaners, but are not chemically identical. Click to learn more and access the Liquinox and Alconox msds.

Read the full story

Posted in Alconox, Ask Alconox, Laboratory, Liquinox, Manual Lab Cleaning, Medical Device, Pharmaceutical, Validation0 Comments

Solution Preparation Tank

Cleaning Titanium Dioxide from Tanks

Residual titanium dioxide (TiO2) can certainly pose issues due to it’s nature in the presence of heat. To remove TiO2 from tanks using CIP sprayballs, it is important to use….

Read the full story

Posted in Biotechnology, Cosmetic, Keylajet, Pharmaceutical, Solujet0 Comments

Biocompatibility Testing for Pyrogens

Your detergents have corresponding biocompatibility data. Our medical devices must be pyrogen and endotoxin free. Someone mentioned that biocompatibility tested detergents, like yours, will be free of organic residues like endotoxins and pyrogens. Is this true?

Read the full story

Posted in Biotechnology, Medical Device, Pharmaceutical0 Comments

Manual Cleaning A 100 Gallon Mixer

Q: We are looking for detergent and process recommendations for manual cleaning of a 100 gallon mixer. We make one product in the mixer which contains water, modified food starch, acidic buffers, sucralose and preservative. Currently when cleaning, we boil for 1 hour at 90°C, then cool, drain and soak in cool water while using the mixing blades.  Scrub brushes and a spray hosing follows that. The mixer is made from stainless steel.

Read the full story

Posted in Alconox, Citranox, Liquinox, Pharmaceutical2 Comments