Archive | Pharmaceutical

Calculating Cleaning Agent Safety Based Limits

Q. Does Alconox provide information on calculating cleaning agent safety based limits?
A. Cleaning agent safety based limits are typically calculated from a safety factor of an acceptable daily intake (ADI), a (1/1000 or more) reduction of an LD50 preferably by the same route of administration, or reproductive hazard levels. Alconox, Inc Pharmaceutical Cleaning Validation References PDF has an entire section dedicated to cleaning agent safety based limits.

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Posted in Biotechnology, Medical Device, Pharmaceutical0 Comments

CIP

How much CIP detergent needed?

Q: We are starting a new bioprocessing facility where we will be cleaning stainless steel tanks via a Clean-In-Place sprayball system? How do I approximate how much detergent I will need? We are considering Alcojet or Solujet, follow by an acidic rinse with Citrajet. Is this a good plan? Any advice? A: A good rule of thumb for tis you need about….

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Posted in Biotechnology, Citrajet, Cosmetic, Keylajet, Pharmaceutical, Solujet0 Comments

Come See Alconox, Inc. at INTERPHEX 2017

Join us in NY, NY on March 21-23, 2017 for INTERPHEX — the premier pharmaceutical, biotechnology, and medical device development and manufacturing show. Come visit our booth, #2226 to receive our unique gifts, expert technical support for critical cleaning applications, and detergent samples.

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Posted in Biotechnology, Medical Device, News, Pharmaceutical0 Comments

Removing Protein from Cell Culture Containers

Q: What do you recommend for removing protein from cell culture containers?
A. To clean cell culture containers and remove protein, use a freshly made solution of our enzymatic detergent….

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Posted in Biotechnology, Manual Lab Cleaning, Pharmaceutical, Tergazyme0 Comments

http://www.wves.org/environmentally-friendly-choice-electronic-cigarette

Cleaning E-cigarette Manufacturing Equipment

We are manufacturing e-cigarettes and need to find a good cleaner for our equipment. We are removing residues of essential oils, glycerin and flavor enhancers with an automated clean-in-place. Our tank is 500 gallons. We are unsure how much cleaner we need. Can you at Alconox Inc. help? We would recommend hot Solujet detergent. Learn more…

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Posted in Pharmaceutical, Solujet0 Comments

Guidelines for Triple Rinsing

Q. is there any industry guidance on triple rinsing…any literature that you know of that this is the accepted standard for manual cleaning that you could provide me?
A. To our knowledge, there are no authoritative source documents to define how many times you should rinse glassware. The logic behind a triple rinse is that, in filling and emptying a vessel three times with water, each time you are diluting by 2 orders of magnitude. In theory . . .

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Posted in Cosmetic, Laboratory, Medical Device, Pharmaceutical0 Comments

All About Rinse Aids

There are basically three kinds of rinse aids: Hydrophobic rinse aids that leave behind a residue, surfactants that wet surfaces and allow rinse water to sheet off a surface without leaving behind droplets, and acid rinses that dissolve insoluble alkaline salt residues.

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Posted in Biotechnology, Citrajet, Cosmetic, Environmental, Laboratory, Medical Device, Metalworking & Precision Manufacturing, Pharmaceutical, SolujetComments Off on All About Rinse Aids

How to: Remove Residual Silicone Oils

Q. We are currently using a solvent and we want to switch to a safer product. Do you have a detergent that can assist in the removal of residue silicone oils that are left in medical device mold inserts manufactured using clear rubber material? We are currently using a solvent and we want to switch to a safer product, such as a water-based cleaner. Will Alconox detergent work as your web page says without ultrasonic?

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Posted in Alconox, Biotechnology, Medical Device, Pharmaceutical0 Comments

http://en.wikipedia.org/wiki/Bubble_ring

One Detergent to Clean Them All?

Q: We are advising a mid-sized pharmaceutical company. If we use multiple cleaning agents within a facility, the cleaning program may be a bit difficult to manage (chances are that the operators may use the incorrect cleaning agent for the product) and also the cleaning validation will be a more complex exercise. What would you recommend for general cleaning? Which is preferred between acidic and alkaline cleaning agent to start with?

A: Thank you for your inquiry for a multi use detergent as this is certainly not an uncommon question. Learn more….

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Posted in Biotechnology, Detergents, Laboratory, Pharmaceutical0 Comments

Cleaning a V Blender

Q. How would you clean a 3 cu ft V blender?
A: I recommend using a 0.5% Solujet® solution of 12 L to clean the 3 cu ft V blender followed by 2 rinses and then a 3rd sampling rinse. You may wish

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Posted in Cosmetic, Medical Device, Pharmaceutical, Solujet0 Comments