Categorized | Citranox, Pharmaceutical

Pharmaceutical Cleaning: Insoluble Tablet Coating

Q. Water insoluble tablet coatings used for solid dose enteric pharmaceutical tablets are very difficult to clean from coating equipment and tablet presses. It was hard to validate the equipment and prevent cross contamination.  Can Alconox Inc. assist?

A. The use of hot 140F/60C Citranox® Liquid Acid Cleaner and Detergent at a 2% concentration allows  successful removal of water insoluble salts used in these coatings.  This would be the recommendation for manual methods including scrubbing, soaking and sonication.

If the tablet press parts are being cleaning in a washer, high pressure sprayer or has its own clean-in-place system, we would go with a low foaming equivalent detergent, specifically: Citrajet® Low-Foam Liquid Acid Cleaner/Rinse.

In either case, initial rinsing should be at or near wash temperatures to avoid breaking emulsions that may have formed.  Subsequent rinses can be at ambient.

The following whitepapers will provide assistance with pharmaceutical, biopharma and related cleaning validation efforts:

We are happy to discuss your individual pharmaceutical cleaning needs at any time.

To request any Alconox Inc. detergents for free, please complete the questionnaire at Get Sample. For more information about any one of our Alconox, Inc. detergents, consult the technical bulletin for each product. Or click here to access each of our detergent’s Safety Data Sheets.

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Contact us any time: cleaning@alconox.com