Categorized | Biotechnology, Pharmaceutical

Replacing Isopropyl Alcohol in Pharmaceutical Cleaning

Q. I’ve been told that we should no longer use isopropyl alcohol (IPA) for cleaning our pharmaceutical equipment. What should we use instead?

A. In pharmaceutical cleaning applications, isopropyl alcohol is less than ideal. Alcohol will clean residues which are soluble in alcohol, but that is a limited range.  Using critical cleaning, aqueous detergents are far more robust and will allow for more effective cleaning processes.

Well-built detergents will emulsify a far wider spectrum of active pharmaceutical ingredients and other residues. The type of detergent to choose as a replacement for IPA will depend on whether cleaning will be manual or washer/sprayer/CIP, which would necessitate a low foaming detergent.  Other factors are is the residue organic or inorganic.  Still other options can include phosphate or phosphate-free, and a preference for a powdered or liquid concentrate.  Having a suite of these detergent combinations allows for any residue, cleaning mechanism and substrate to be tackled effectively.  Again, using just IPA cannot accomplish this.  

Finally, vast amounts of IPA to drain may require government or other regulatory licensing depending on your location and municipality.

To request an Alconox Inc. detergent for free, please complete the questionnaire at Get Sample. For more information about any one of our Alconox Inc. detergents, consult the technical bulletin for each product. Or click here to access each of our detergent’s Safety Data Sheets.

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