TechNotes

Q: We are cleaning heavy scale compounds of Ca, Mg, carbonates, phosphates and organic matter from reverse osmosis (RO) membranes. Can you tell us some cleaning best practices and recommend a detergent?

A. If the organic matter is significant, a two-step process, cleaning by re-circulation or soaking (re-circulation may be more effective) could be needed. If the organic matter is biologic in nature, we would recommend Tergazyme® Enzyme-Active Powdered Detergent which is both a powerful emulsifier along with protein enzymes. If the organic residue is more of an oily nature…

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Q: Can you tell me if Liquinox can clean/remove pharmaceutical probiotics? We use this product to clean our packaging lines. We have a customer who is looking to have us package their probiotic product.

A: Liquinox® Critical Cleaning Liquid Detergent is an excellent emulsifier of organic and oily residues. It will do the job. Best practice, however, would be to incorporate a powerful emulsifier of organic and oily residues, along with enhanced protein removal. 

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We are cleaning a V Mixer made of NSF Stainless steel and we are using it to mix different protein powders, amino acids, and herbs for dietary supplements. It is small enough to be cleaned by hand but not small enough for any type of sink. I was advised to buy your Citranox product. Is that the best detergent for this job?  

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Q. I’m a Ph.D. student and I’m studying protein interactions. We have been using Tergazyme to clean lenses and cuvettes for our light scattering equipment and it works flawlessly! My question is: Does Tergazyme enzyme detergent have any disinfection properties, like killing of bacteria such as E. coli?

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Q:  You recently sent a sample of Tergazyme detergent for a tough cleaning challenge and it worked better than anything we had previously tried. I realize this must be due to the enzyme component. What information can you provide me on how enzyme detergents work, so I can share it with our decision makers / executives who want to better understand why this detergent got such different results?

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Q. How do you remove protein out of pipes, centrifuges and tanks in a CIP environment with water temperatures averaging 20C?

A. In a cooler temperature environment, consider adding an enzymatic cleaner to your alkaline/acidic CIP routine. A product like Tergazyme® Enzyme-Active Powdered Detergent, which contains both protease and surfactants, is not only efficient at removing the biofilm, but will also slow down the formation of biofilm and allow the regular cleaning cycle to clean effectively for more cycles.

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Q. We use Tergazyme to clean our TFF cassettes and it’s working well. However, we are moving to CIP cleaning in an automated, high pressure environment and are worried about foaming. Do we stick with Tergazyme or is there a better detergent we should use?

A. Tergazyme® Enzyme-Active Powdered Detergent is of an excellent choice for cleaning TFF cassettes. Even as you move to more high pressure, automated CIP method, Tergazyme detergent will likely continue to work well. That’s because….

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Video: Tergazyme® Enzyme Active Powdered Detergent is a concentrated, anionic detergent with a proteolytic enzyme for manual and ultrasonic cleaning. Excellent for organic and oily residues in addition to enhanced removal of proteinaceous soils, tissue, biofilms, blood and bodily fluids from glassware, metals, plastic, ceramic, porcelain, elastomers and fiberglass with no interfering residues.

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Q. How can I clean proteins, RNA, and DNA from laboratory equipment?

A. Thank you for your question concerning cleaning proteins, RNA and DNA from laboratory equipment.

We will address each separately . . .

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What is the difference between Tergazyme and Alconox? Is one better? Is one more mild?

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