Pharmaceutical

Q. We cannot determine residues of detergent and we cannot validate the detergent. We are choosing a new detergent that cleans protein and this detergent must be neutral to titanium. We don’t want corosion trouble. The titanium equipment’s manufacturer recommends to use neutral detergents.

A. While much titanium equipment can be cleaned with non-neutral detergents, if the specific manufacturer recommends a neutral range detergent we can certainly suggest one. We recommend cleaning with a 1% Liquinox solution which has a neutral range pH of 8.5.

Q. Currently I am not using a cleaner, just mechanical cleaning with water. I am cleaning batch tanks used to produce colloidal silver. The only two ingredients in the tank are pure silver electrodes and distilled water. The cleaner needs to be FDA-approved for internal use after the cleaning cycle.

Q. I am planning to use Luminox, to clean pharmaceutical packaging production equipment (automated filling machines, liquid blenders, etc.) , but I am not sure that it is certified for pharmaceutical industry and can be used industry leaders.

Q. Which Alconox detergents would successfully clean Metaxalene?

A. Metaxalene contains amide, ester and ether groups. The solubility is unknown. Alconox recommends using Liquinox or Citranox. For more information about Liquinox and Citranox, click to download each detergent’s technical bulletin and/or Material Data Safety Sheet (MSDS). You can also request a free sample by completing the questionnaire at Get Sample.

Q. How do I find an analytical method to detect trace residues of Alconox brand cleaners for a cleaning validation?
A. The best place to find analytical methods for detergent residue detection for either a pharmaceutical or medical device cleaning validation is by downloading our Pharmaceutical Cleaning Validation document.