Pharmaceutical

Q. I am manufacturing engineer and I have a question regarding Alconox powdered precision cleaner. Your catalog says that the minimum cleaning temperature when using Alconox should be ambient temperature. How much is Ambient Temperature exactly? Our clean rooms have a temperature of approximately 21°C, which means that after heating it for preparation it will cool down through the day. Should we keep it over 21 °C?

For best results removing water insoluble pharmaceutical residues in a labware washer there are several factors to pay attention to:

1) Be sure to load glassware separated from other glassware in a way that will not trap wash solution between pieces of touching glassware.

2) Be sure to load glassware tilted in a position that will drain all surfaces so as to avoid any upturned “cup” that will retain wash solution and carry it in the rinse cycle where it gets redeposited all over other glassware – a classic example of this happens when you load a graduated cylinder straight upright and the base of the cylinder holds wash solution – it is best to load graduated cylinders at a bit of an angle.

Pharmaceutical and Biotechnology processing equipment can be made residue-free clean with Alconox Critical Cleaning Detergents. Alconox, Inc. detergents are available worldwide with consistent formulations, certificates of analysis, ingredient toxicity data, shelf life information, residue sampling techniques, ingredients disclosure, analytic methods, lot number tracking, and validation support.

Q. We need to replace sodium hypochlorite soak solution that we use during the inital cleaning of glassware that was used for any biological fluids.
A. Use a freshly made 1% Tergazyme (1.25 oz/gal or 10 mL/L) in warm water (not exceeding 130 deg F) followed by a thorough warm water rinse to remove biological fluids … Read More.

Q. We cannot determine residues of detergent and we cannot validate the detergent. We are choosing a new detergent that cleans protein and this detergent must be neutral to titanium. We don’t want corosion trouble. The titanium equipment’s manufacturer recommends to use neutral detergents.

A. While much titanium equipment can be cleaned with non-neutral detergents, if the specific manufacturer recommends a neutral range detergent we can certainly suggest one. We recommend cleaning with a 1% Liquinox solution which has a neutral range pH of 8.5.