Medical Device

Q. Does Alconox provide information on calculating cleaning agent safety based limits?
A. Cleaning agent safety based limits are typically calculated from a safety factor of an acceptable daily intake (ADI), a (1/1000 or more) reduction of an LD50 preferably by the same route of administration, or reproductive hazard levels. Alconox, Inc Pharmaceutical Cleaning Validation References PDF has an entire section dedicated to cleaning agent safety based limits.

Intuition, logic, and maybe even some experiences, can lead us to believe more detergent is better.  These everyday experiences where it might apply include your washing machine, dishwasher, or even your hands in the bathroom sink.  But, what is actually meant by better?  This is where concentration and detergency come into play, terms you may see in our literature and documentation, as well as our responses and solutions to cleaning challenges.

Q. How to determine appropriate temperature to clean parts with ultrasonic cleaner?

A. In general, every 10 deg C you go up in temperature doubles the cleaning speed. The faster you want to clean the hotter you should get.

There is a theoretical optimal ultrasonic cavitation temperature at around 70 deg C depending on the exact concentration of detergent. Even though in theory cavitation…

Q. Do you have a recommended swab detection method for residual detergent?

A. We most certainly do.  It is suggested to use a swabbing area of 5 cm X 5 cm. Where extreme low level acceptance criteria on a low recovery residue, i.e. some product residues, it can help to….

Q. The color of our Liquinox is slightly different by lot number. Why is this happening? Is there an issue, perhaps we have done something wrong with storage?  

A. Do not fear! These color variations are normal. There is a range of acceptable color differences in Liquinox detergent. Differences in the age and storage conditions of the raw materials and of the Liquinox detergent itself will account for differences in color