Q. Currently using Alconox, but are considering a switch to Liquinox. What are the recommendations and concerns with switching from Alconox to Liquinox? What are the difference in ingredients between Alconox and Liquinox? Do we need to do a validation? A. Alconox® Powdered Precision Cleaner and Liquinox® Critical Cleaning Liquid Detergent, are functionally equivalent … [Read more...] about Differences between Alconox and Liquinox
Q. Our pharmaceutical company is transferring product manufacture to a different one of our facilities. We used a CIP cleaning process with Citrajet detergent and are going to have to perform validation and verification tests again. What information do we need for our testing? Chemical properties might be helpful as well as the science on how this chemical works. We would also … [Read more...] about Clean in place (CIP) with Citrajet Detergent
Q. What is the shelf life of Liquinox concentrate after it has been opened? A. Liquinox® Critical Cleaning Liquid Detergent conforms to its 2 years from date of manufacture shelf life as long as the bottle is kept closed in between use. Incidental opening and closing of the bottle to pour out liquid for use, and the resulting increased head space air in the bottle, container, … [Read more...] about Shelf Life of Opened Detergent Concentrate
Q. What is a surfactant? A. Good question as these are key constituents of typical aqueous detergents. Other typical components of aqueous cleaners are, chelators, builders and additives (ex. corrosion inhibition). Surfactant is short for “surface active agent,” it is an organic molecule with a hydrophobic (water-hating/oil-loving) end and a hydrophilic (water-loving) end. … [Read more...] about What is a Surfactant?
Q. Do you have a recommended swab detection method for residual detergent? A. We most certainly do. It is suggested to use a swabbing area of 5 cm X 5 cm. Where extreme low level acceptance criteria on a low recovery residue, i.e. some product residues, it can help to use a 10X10 cm area. However, for detergent residues, you should not have to go to a 10X10 cm area in order … [Read more...] about Residue Detection: Swab Method