Pharmacuetical Cleaning Olanzapine

Q. Which detergent should be used for manual & CIP pharmacuetical cleaning of Olanzapine?

A. Olanzapine has a predicted water solubility of 0.5 mg/mL making is very slightly soluble in water. There are n-heterocyclic groups which means it can be cleaned by either an acid or an alkali, possibly slightly better by an alkali. This is a medium small molecule that is slightly polar and should be emulsifiable.

Use Solujet for spray CIP cleaning. Solujet can also be used for manual cleaning (operators have to wear protective gloves & eyewear when handling), although Liquinox would also work for manual cleaning.

Click to view technical bulletins and MSDS for Solujet, Low-foaming Phosphate-Free Liquid and Liquinox, Critical- Cleaning Liquid Detergent.