Published: March 14, 2022
Q: Our CIP system is struggling with a new product leaving drug residues of magnesium oxide and calcium silicate. We recently switched from a competitor to Solujet which worked very well but not on this newest product. What should we be doing?
A: Drug residues can always be a challenge. Pharmaceutical products containing mineral ingredients like magnesium oxide and calcium silicate MgO and Ca2SiO4 will have adherent drug residues that tie up chelation and alkaline hydrolysis capability of the detergent. By increasing concentration from typical 1-2% up to 5% or higher, improved performance would be expected because the amount of residue that can be carried away is increased..
If the higher concentration of Solujet does not work, then we might need to consider using Keylajet® Low-foaming Chelating High Alkaline Liquid. Keylajet detergent is a powerful cleaner of challenging residues, and has notably increased chelation and alkalinity over Solujet detergent. We can share acceptable daily exposure data for Solujet and Keylajet to help determine residue acceptance limits for cleaning validation if the switch is required.
To request these or any Alconox Inc. detergent for free, please complete the questionnaire at Get Sample. For more information about any one of our Alconox Inc. detergents, consult the technical bulletin for each product. Or click here to access each of our detergent’s Safety Data Sheets.
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