Pharmaceutical Testing – Oral Toxicity

Q. How is Oral Toxicity defined and reported?

A. Pharmaceutical testing for Oral toxicity is reported as an Oral LD50, the lethal dose at which 50 percent of a population of animals will die when exposed orally. Oral toxicity is often used to estimate toxicity from other routes of exposure by using safety factors ranging from 1/1,000 to 1/100,000 of an Oral LD50. Lower safety factors are used for shorter duration exposure devices that are less invasive.

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