Q. My question is related to a minimum detergent concentration. We manually wash labware of all sizes in a 0.3% Liquinox solution. We also pre-wash and control our parts load. We replace the wash water with a fresh water plus detergent load routinely. We test the labware loads for soil and/or detergent residue using TOC analysis. We rarely have failures. We want to change our … [Read more...] about Minimum Detergent Concentration?
Q. What is TOC and is TOC an acceptable residue detection method for Alconox Brand Aqueous Cleaners? A. Total organic carbon (TOC) is the amount of carbon bound in an organic compound and is often used as a non-specific indicator of water quality or cleanliness of pharmaceutical manufacturing equipment. A typical analysis for TOC measures both the total carbon present as … [Read more...] about What is a TOC Residue Detection Method?
Q. We are going to start a cleaning validation with Alconox and I was wondering what kind of support you could offer? I would be interested in seeing any protocols and sample prep suggestions. I tried some experiments with Linearity for Alconox on the TOC and had some difficulties. A. Thanks for your question about linearity issues with detecting residues of Alconox using … [Read more...] about How to: Pharma Cleaning Validation