Archive | Biotechnology

How to Clean Labware: Removing Algae

Q. We are a large energy company working with algae.  It is proving tough to remove from glass and labware. We are using Liquinox detergent currently, which is good.  Anything better? Eventually we would like to move to cleaning these in our washer.

A. Algae, and the viscous oils that you are working with, require not just powerful emulsifiers….

Read the full story

Posted in Alcojet, Biotechnology, Detojet, Environmental, Laboratory, Liquinox, Tergazyme0 Comments

Monitoring Bath Life Extension in Medical Device Cleaning

Q. What is the best way to monitor for bath life extension?
A.To avoid potential for cross contamination, only freshly made up cleaning solutions should be used for the highest levels of critical cleaning. In general, a pH change of 1 unit towards neutral indicates an exhausted cleaning solution. Bath life can be extended. Learn How.

Read the full story

Posted in Biotechnology, Cosmetic, Healthcare, Laboratory, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments

Continuous processing protein

Alconox, Inc. Detergents and Continuous Bioprocessing

Q. How can Alconox detergents assist with our movement to continuous bioprocessing? A: Continuous bioprocessing is an exciting newcomer to the biotech realm. It has been used in industries such as food and chemicals for some time, effectively so. With improvements in cell culture perfusion, and the many forms of disposable technologies on the market, footprints can be reduced making continuous processing for biotech products a reality for many applications.

Read the full story

Posted in Biotechnology, Citrajet, Detonox, Filter, Liquinox, Solujet, Tergazyme0 Comments

Risk Based Limits and Pharmaceutical Cleaning

Q. We are moving from LD50 data to ADE (PDE) limits based on HBELs. This is allowing us to eliminate disposables for low-risk products.  How do I know which can be manually cleaned and which needs to be in a washer? Can manual cleaning be validated?

A. Many pharma and biotech companies have been moving to Health-Based Exposure Limits (HBELs) meaning Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) limits as detergent residue limits.    

Read the full story

Posted in Biotechnology, Pharmaceutical, Validation0 Comments

Solution Preparation Tank

Cleaning Titanium Dioxide from Tanks

Residual titanium dioxide (TiO2) can certainly pose issues due to it’s nature in the presence of heat. To remove TiO2 from tanks using CIP sprayballs, it is important to use….

Read the full story

Posted in Biotechnology, Cosmetic, Keylajet, Pharmaceutical, Solujet0 Comments

Biocompatibility Testing for Pyrogens

Your detergents have corresponding biocompatibility data. Our medical devices must be pyrogen and endotoxin free. Someone mentioned that biocompatibility tested detergents, like yours, will be free of organic residues like endotoxins and pyrogens. Is this true?

Read the full story

Posted in Biotechnology, Medical Device, Pharmaceutical0 Comments

Cleaning Pharmaceutical Probiotics

Q: Can you tell me if Liquinox can clean/remove pharmaceutical probiotics? We use this product to clean our packaging lines. We have a customer who is looking to have us package their probiotic product.

A: Liquinox® Critical Cleaning Liquid Detergent is an excellent emulsifier of organic and oily residues. It will do the job. Best practice, however, would be to incorporate a powerful emulsifier of organic and oily residues, along with enhanced protein removal. 

Read the full story

Posted in Biotechnology, Liquinox, Pharmaceutical, Tergazyme0 Comments

closed bioprocessing

Closed Bioprocessing Cleaning Recommendations

Q: We are a mid sized small biomolecule drug manufacturer and currently use several Alconox, Inc. products in our cleanroom and manufacturing suites.  We are looking at implement (functionally) closed bioprocessing.  Are there any recommendations you can provide?
A: Some time ago, I heard a senior executive of a large biotech company express a desire to produce drugs in a “conference room.”  That day is pretty much here. 

Read the full story

Posted in Biotechnology, Pharmaceutical0 Comments

disposal

Disposal of Alconox, Inc. Detergents

What is the proper way to dispose of your detergents? Detergent disposal in a proper manner is an integral part of a robust cleaning program regardless of scale or industry. Alconox, Inc. detergents are biodegradable….

Read the full story

Posted in Aerospace, Alcojet, Alconox, Alcotabs, Biotechnology, Citrajet, Citranox, Cosmetic, Detergent 8, Detergents, Detojet, Electronic, Environmental, Filter, Food & Beverage, Foodservice, Healthcare, Laboratory, Liquinox, Luminox, Medical Device, Metalworking & Precision Manufacturing, Pharmaceutical, Solujet, Tergajet, Tergazyme0 Comments

Industrial Ultrasonic Cleaning 101

Find answers to questions such as: What is ultrasonic tank cleaning? Which industries employ? What Alconox brands are ideal for ultrasonic tank cleaning?

Read the full story

Posted in Alconox, Biotechnology, Citranox, Cosmetic, Detonox, Environmental, Healthcare, Liquinox, Manual Lab Cleaning, Medical Device, Pharmaceutical0 Comments