Archive | Industry

Removing Protein in Pharmaceutical and Biotech Manufacturing

Q. How do you remove protein out of pipes, centrifuges and tanks in a CIP environment with water temperatures averaging 20C?

A. In a cooler temperature environment, consider adding an enzymatic cleaner to your alkaline/acidic CIP routine. A product like Tergazyme® Enzyme-Active Powdered Detergent, which contains both protease and surfactants, is not only efficient at removing the biofilm, but will also slow down the formation of biofilm and allow the regular cleaning cycle to clean effectively for more cycles.

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Posted in Biotechnology, Pharmaceutical, Tergazyme0 Comments

TFF Cassette Cleaning

Q. We use Tergazyme to clean our TFF cassettes and it’s working well. However, we are moving to CIP cleaning in an automated, high pressure environment and are worried about foaming. Do we stick with Tergazyme or is there a better detergent we should use?

A. Tergazyme® Enzyme-Active Powdered Detergent is of an excellent choice for cleaning TFF cassettes. Even as you move to more high pressure, automated CIP method, Tergazyme detergent will likely continue to work well. That’s because….

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Posted in Biotechnology, Detojet, Tergazyme0 Comments

DI Water Wettability

Medical Device Cleaning – Rinsing Silicone O-rings

Q. I would like to know if our rinsing process (Ultrasonic Cleaning with Sterile distilled water for 10 minutes) is appropriate for rinse off. Parts we are cleaning: 150″ Silicone O-Rings.
A. Thanks for your question about the sufficiency of a 10 min. distilled water rinse in ultrasonics for cleaning medical device related silicon o-rings. Distilled water is generally fine for rinsing. The best rinse is …

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Posted in Medical Device0 Comments

carbide

How To Clean Carbide

Q:I was wondering if you have a product that I can use in an ultrasonic cleaner to clean tungsten carbide that would not leach out cobalt? That also can be disposed of down a drain?

A: Tungsten carbide (WC) cleaning comes with some inherent issues, and the cleaning cycle that accompanies it will depend entirely on the feed stock (components to be cleaned) that the process comes from. This is where Alconox, Inc., as the critical cleaning experts, excel from our experience and vast pool of applications to draw upon.

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Posted in Alconox, Citranox, Detonox, Keylajet, Metalworking & Precision Manufacturing0 Comments

Lab Glassware

Labware Cleaning: Solujet Leaving Ring

Q. It appears that the Solujet is leaving a ring on some of the labware that cannot be removed. What is this ring (sodium silicate?)? How do we remove it? The labware has not been completely submerged. We have just added the Solujet soak for some labware that may have stubborn organics. We have been giving the labware a 4 hour soak in 1% Solujet, followed by warm tap water rinse then wash with Liquinox followed by 3x DI rinse.

Click for the Answer.

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Posted in Laboratory, Liquinox, Manual Lab Cleaning, Solujet0 Comments

Passivate: Citric Acid Option with Citranox and Citrajet Detergents

Surface contamination interferes with formation of protective oxide coating on stainless steel thereby leaving it open to corrosion. The stainless steel needs passivation.

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Posted in Citrajet, Citranox, Medical Device0 Comments

Flux Residue Removal

Q. I am seeing a white powder around solder joints on PCBs.  Is this solder flux? We use Detergent 8 for cleaning. Do you know why this is happening and how to stop or remove it?
A. There are several ways of approaching this common issue of solder flux and its removal. For example, One way to fix this problem is to lower the temperature when soldering. In another scenario, a leading aerospace manufacturer studied putting potassium silicate (10 mL in 10 L) into the Detergent 8 bath to act as an inhibitor to stop the formation of these white salts.

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Posted in Citrajet, Citranox, Detergent 8, Electronic0 Comments

Clean-in-place (CIP) with Citrajet Detergent

Q. Our pharmaceutical company is transferring product manufacture to a different one our facilities. We used a CIP cleaning process with Citrajet and are going to have to perform validation and verification tests again. What information do we need for our testing? Chemical properties might be helpful as well as the science on how this chemical works. We would also need information on disposal and the requirements for allowing this to flow to normal process drains.

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Posted in Citrajet, Keylajet, Pharmaceutical, Solujet, Validation0 Comments

Cleaning Carbon Deposit Swirls On Alumina Parts

Q. Our parts, made of 99.5% alumina, have carbon deposits that show up after our brazing process. We do not use a flux for our ceramic parts; we high-temp fire a moly/manganese painted paste onto the ceramic. The part is then sent out for nickel plating to prevent corrosion of the moly manganese metallization areas. The next step is our brazing.

We are not seeing any spots on the parts before brazing, but as we continue through 5 brazing cycles and braze in a hydrogen/Nitrogen furnace with the cusil braze rings, we see black spots forming that show up as high-carbon deposits with the SEM data…

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Posted in Citranox, Metalworking & Precision Manufacturing0 Comments

Lab Test Tubes

Minimum Detergent Concentration?

My question is related to a minimum detergent concentration.  We manually wash labware of all sizes in 0.3% Liquinox solution. We also pre-wash or pre-rinse the labware and control our parts load.  We rarely have failures. We want to change our protocol to extend the wash water use for one day instead of based on a numerical parts load.  Do you think a 0.3% Liquinox concentration is sufficient detergent capacity to go an entire day?

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Posted in Laboratory, Liquinox, Manual Lab Cleaning0 Comments