Biotechnology

Q. What does “detergent is the last to leave the equipment surface” after rinsing mean? This seems like a broad statement, can it be supported by literature/documentation?
A. The only source of “detergent last to rinse” that I am aware of is based on the physical behavior of surface active agents and the interchangeable use of the word detergent and surfactant in common usage. More properly you should say the surfactant is the last to rinse. Learn More about Surfactant.

Learn the proper way to make a 1% detergent solution by following these four simple steps. To make a 2% detergent solution, simply double up the amount! Alconox Inc. aqueous detergents are sold in concentrate. To use, dilute according to package instructions. Most Alconox Inc. products require only a 1-2% dilution for optimal use.

Q: Many of your Tergazyme related TechNotes and recommendations include warm temperatures. Warm temperatures can still denature some hormones and proteins thus causing cleaning problems. I would probably start with a cool (room temp or cooler) rinse (water). Then move to the 1-2% cleaning solution in warmer temperatures. Agreed?

Q: You recently recommended Detonox detergent for a tough cleaning challenge we had. You rushed a sample over and it worked fantastically. I have review your technical bulletin, but is there anything else you can tell me about it? Is it better than Alconox and Liquinox? It seems great.

A: Thank you for the feedback and question…..

Q: We are a mid sized small biomolecule drug manufacturer and currently use several Alconox, Inc. products in our cleanroom and manufacturing suites.  We are looking at implement (functionally) closed bioprocessing.  Are there any recommendations you can provide?
A: Some time ago, I heard a senior executive of a large biotech company express a desire to produce drugs in a “conference room.”  That day is pretty much here.