Closed Bioprocessing Cleaning Recommendations
Q: We are a mid sized small biomolecule drug manufacturer and currently use several Alconox, Inc. products in our cleanroom and manufacturing suites. We are looking at implement (functionally) closed bioprocessing. Are there any recommendations you can provide?
A: Some time ago, I heard a senior executive of a large biotech company express a desire to produce drugs in a “conference room.” That day is pretty much here.
Defining Free Rinsing Detergent
A non-free rinsing cleaner might contain fragrances that were designed to deposit and leave a fresh scent, or it might contain corrosion inhibitors that are designed to deposit and leave behind an anti-corrosion film.
Alconox, Inc, cleaners are free rinsing detergents and do not leave deposits on substrates after rinsing.
What is Critical Cleaning?
Q: What precisely is critical cleaning? How does it differ from “regular” cleaning? A: It refers to a very specific type of cleaning. It is where the cleaning itself impacts the value of the finished output from whatever residue/contaminant is being cleaned.
Cleaning pH Probes & Dissolved Oxygen Probes
Q. Which Alconox Inc. brand cleaner is well suited for cleaning pH and dissolved oxygen probes?
A. Dissolved oxygen and pH probes used in fermentation vessels can get buildup from the fermentation media that degrades the probe performance and increases the likelihood of batch to batch contamination. Even CIP systems cannot always reliably clean the port crevices and o-rings.
How Does Tergazyme Enzyme Detergent Work?
Q: You recently sent a sample of Tergazyme detergent for a tough biologic cleaning challenge and it worked better than anything we had previously tried. I realize this must be due to the enzyme component. What information can you provide me on how enzyme detergents work, so I can share it with our decision makers / executives who want to better understand why this detergent got such different results?