Pharmaceutical

Q. Is there any PFOA or PFOS in any Alconox cleaner?
A. PFOA and PFOS are perfluoro-octanoic acid and perfluoro-octane sulfonate. None of the Alconox, Inc brand cleaners contains PFOA or PFOS ingredients.

Q. Water insoluble tablet coatings used for solid dose enteric pharmaceutical tablets are very difficult to clean from coating equipment. It was hard to validate the equipment and prevent cross contamination.

A. The use of hot 140 deg F 2% Citranox for manual cleaning allowed succesfull removal of water insoluble salts used in these coatings. The references in the Pharmaceutical Cleaning Validation References PDF will help you with validation. And if you have a question for our experts about critical cleaning, please visit Ask Alconox.

Q: We are looking for detergent and process recommendations for manual cleaning of a 100 gallon mixer. We make one product in the mixer which contains water, starch, acidic buffers, sucralose and preservative. Currently when cleaning, we boil for 1 hour at 90°C, then cool, drain and soak in cool water while using the mixing blades.  Scrub brushes and a spray hosing follows that. The mixer is made from stainless steel.

Q. Our pharmaceutical company is transferring product manufacture to a different one our facilities. We used a CIP cleaning process with Citrajet and are going to have to perform validation and verification tests again. What information do we need for our testing? Chemical properties might be helpful as well as the science on how this chemical works. We would also need information on disposal and the requirements for allowing this to flow to normal process drains.

Visit Alconox, Inc. at the ISPE 2019 Annual Meeting and Expo in Las Vegas, NV, October 27-30. Stop by Booth #101 to receive our unique gifts, expert technical support for your critical cleaning applications, and detergent samples.