Drug Residues: MgO and Ca2SiO4
Our CIP system is struggling with a new product leaving drug residues of magnesium oxide and calcium silicate. We recently switched from a competitor to Solujet which worked very well but not on this newest product. What should we be doing?
How to verify brushes are clean?
Q: We were recently audited and we were asked: how do you prove that the brushes you are using are not cross-contaminating the equipment surface with residues?
A: How do you prove brushes are clean, or for that matter, any cleaning device is itself clean, is an excellent question. This can apply to any reusable instrument, cloths, tube brushes, sponges, etc.
Extra Foam Please?
Q: Since foaming is so critical to COP methods, should operators be agitating the solution(s) to produce foam before and during manual cleanings?
A: Mechanical energy, agitation, and plain old elbow grease, are vital weapons in cleaning and Clean-Out-Of-Place applications. So we would recommend that wherever possible, mechanical energy be applied to remove unwanted residues from the surface we are trying to clean. This will
Aqueous Detergents Above Boiling Temperature
Q: Do you have usable detergents above boiling temperature? Any that we could consider that could withstand such high temps?
A: Great question. There are several uses currently in play across many industries where detergents are used at or near boiling temperatures.
For use of detergents above the boiling point, a couple of factors need to be discussed.
Pharmaceutical Cleaning: Rinsing in a Cleanroom
We are a large pharma company. We use Alconox detergent in an ISO 8 cleanroom that does not have a floor drain so rinsing in a cleanroom is a problem. We have a form, fill, seal machine with 2 pumps, tubing, and a hopper that have product contact. They are permanently installed. Can we rinse with tap water if we are sanitizing after the rinse? How much rinsing is required?