Clean in place (CIP) with Citrajet Detergent
Q. Our pharmaceutical company is transferring product manufacture to a different one our facilities. We used a CIP cleaning process with Citrajet and are going to have to perform validation and verification tests again. What information do we need for our testing? Chemical properties might be helpful as well as the science on how this chemical works. We would also need information on disposal and the requirements for allowing this to flow to normal process drains.
Shelf Life of Opened Detergent Concentrate
Q. What is the shelf life of the Liquinox concentrate? A. Liquinox conforms to its 2 year shelf life under typical laboratory storage conditions…
What is a Surfactant?
Q. What is a surfactant? A. Surfactant is short for “surface active agent,” it is an organic molecule with a hydrophobic (water-hating/oil-loving) end and a hydrophilic (water-loving) end.
Calculating Cleaning Agent Safety Based Limits
Q. Does Alconox provide information on calculating cleaning agent safety based limits?
A. Cleaning agent safety based limits are typically calculated from a safety factor of an acceptable daily intake (ADI), a (1/1000 or more) reduction of an LD50 preferably by the same route of administration, or reproductive hazard levels. Alconox, Inc Pharmaceutical Cleaning Validation References PDF has an entire section dedicated to cleaning agent safety based limits.
Residue Detection: Swab Method
Q. Do you have a recommended swab detection method for residual detergent?
A. We most certainly do. It is suggested to use a swabbing area of 5 cm X 5 cm. Where extreme low level acceptance criteria on a low recovery residue, i.e. some product residues, it can help to….