Q. I’ve been told that we should no longer use isopropyl alcohol for cleaning our pharmaceutical equipment. What should we use instead?
A. In pharmaceutical cleaning applications, isopropyl alcohol (IPA) is less than ideal. Alcohol will clean residues which are soluble in alcohol, but that is a limited range. Using critical cleaning, aqueous detergents are a far more robust and will allow for more effective cleaning processes.
February 10th and 11th….Come join Michael Moussourakis, Senior Director, Alconox Inc. and several other industry experts at the PharmaEd Resources Inc. Cleaning Validation Virtual Summit, 2021.
Meet cGMP regulations and stringent cleaning validation standards with CIP detergents from Alconox Inc. Whether you use single pass or recirculation systems, Alconox can provide a detergent ideally suited for your CIP system. Click to watch our latest video to learn best practices for Clean in Place and how to choose the right CIP detergent for your application.
Q. Water insoluble tablet coatings used for solid dose enteric pharmaceutical tablets are very difficult to clean from coating equipment. It was hard to validate the equipment and prevent cross contamination.
A. The use of hot 140 deg F 2% Citranox for manual cleaning allowed succesfull removal of water insoluble salts used in these coatings. The references in the Pharmaceutical Cleaning Validation References PDF will help you with validation. And if you have a question for our experts about critical cleaning, please visit Ask Alconox.
Q. Our pharmaceutical company is transferring product manufacture to a different one our facilities. We used a CIP cleaning process with Citrajet and are going to have to perform validation and verification tests again. What information do we need for our testing? Chemical properties might be helpful as well as the science on how this chemical works. We would also need information on disposal and the requirements for allowing this to flow to normal process drains.