TechNotes

Q. How do you remove protein out of pipes, centrifuges and tanks in a CIP environment with water temperatures averaging 20C?

A. In a cooler temperature environment, consider adding an enzymatic cleaner to your alkaline/acidic CIP routine. A product like Tergazyme® Enzyme-Active Powdered Detergent, which contains both protease and surfactants, is not only efficient at removing the biofilm, but will also slow down the formation of biofilm and allow the regular cleaning cycle to clean effectively for more cycles.

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Q. Does Alconox or any other recommended detergent have animal origins?

A. No. All Alconox, Inc. detergents are free-rinsing, biodegradable and contain no animal derived or genetically modified organism ingredients.

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We are in the process of building a cleanroom for medical device manufacturing. What detergents do you recommend? For cleanroom cleaning, we would recommend liquid concentrate detergents to…..

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What is the difference between Tergazyme and Alconox? Is one better? Is one more mild?

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Q:  What are the differences between an acid vs alkaline cleaner? A:  There are some key difference in choosing the right cleaner for your cleaning needs; the ph of a detergent is one dividing line. Acidic cleaners are commonly used to brighten or etch metals and are effective at removing any mineral deposits or oxidation […]

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Q. Does Alconox provide information on calculating cleaning agent safety based limits?
A. Cleaning agent safety based limits are typically calculated from a safety factor of an acceptable daily intake (ADI), a (1/1000 or more) reduction of an LD50 preferably by the same route of administration, or reproductive hazard levels. Alconox, Inc Pharmaceutical Cleaning Validation References PDF has an entire section dedicated to cleaning agent safety based limits.

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Q: We are starting a new bioprocessing facility where we will be cleaning stainless steel tanks via a Clean-In-Place sprayball system? How do I approximate how much detergent I will need? We are considering Alcojet or Solujet, follow by an acidic rinse with Citrajet. Is this a good plan? Any advice? A: A good rule of thumb for tis you need about….

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Unlike A LEADING CIP CLEANER, Solujet has high wetting surfactants that enhance emulsifying, wetting, dispersing and rinsing. The surfactants allow faster, more efficient cleaning and easier rinsing.

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Join us in NY, NY on March 21-23, 2017 for INTERPHEX — the premier pharmaceutical, biotechnology, and medical device development and manufacturing show. Come visit our booth, #2226 to receive our unique gifts, expert technical support for critical cleaning applications, and detergent samples.

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Q: What do you recommend for removing protein from cell culture containers?
A. To clean cell culture containers and remove protein, use a freshly made solution of our enzymatic detergent….

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