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Published: April 20, 2022

Q: We are in the process of building a cleanroom for medical device manufacturing.  What detergents do you recommend?

A: For cleanroom cleaning, we would recommend liquid concentrate detergents to avoid the creation of powdered clouds in the classified environment.  As part of a cleaning detergent rotation we typically recommend a 0.5% Liquinox® Critical Cleaning Liquid Detergent cleaning with a minimum of a single wet water mop rinse.  This has proven effective in medical device, pharma, biotech and related cleanrooms around the globe.  Most recently, this has included our regulated work in cosmetics and cannabis.

For those who have qualified/validated Detonox® Ultimate Precision Cleaner in difficult residue industries like some cosmetic, biotech and (basically all) cannabis applications, a low 0.5% solution can be similarly used for the cleanroom.  This avoids the need of adding another detergent to your mix.

There are options for enclosed mixing units where powdered APIs and other formulations can be made without clouding risks.  This can of course include powdered detergents.  However, liquid concentrates would provide the most efficient and quick answer to necessary cleaning in cleanroom environments.  Recall, you must always clean before you disinfect.

The lower 0.5% concentration will still provide sufficient detergent capacity for the highly controlled and clean classified space, but allowing for an easy rinse.  The detergent can be used to clean walls, floors, counters and other hard surfaces throughout the cleanroom.  Furthermore, the cleaning actions of Liquinox detergent include the ability to break lipopolysaccharide bonds that form between microbes and a surface, or endotoxins and a surface.  Thus removing the above mentioned residuals.

We are happy to discuss your specific cleanroom cleaning needs any time.

To request this or any Alconox Inc. detergents for free, please complete the questionnaire at Get Sample. For more information about any one of our Alconox Inc. detergents, consult the technical bulletin for each product. Or click here to access each of our detergent’s Safety Data Sheets.

Do you have a critical cleaning question for the experts at Alconox Inc.?  Search TechNotes to see if it’s been answered before or Ask Alconox.


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