Laboratory Cleaning: Eliminating Residual Nitrogen
If your concern is residual nitrogen interfering with analysis, we recommend Liquinox® Critical Cleaning Liquid Detergent. Liquinox is phosphate-free and is completely free-rinsing.
Residue Detection: Swab Method
Q. Do you have a recommended swab detection method for residual detergent?
A. We most certainly do. It is suggested to use a swabbing area of 5 cm X 5 cm. Where extreme low level acceptance criteria on a low recovery residue, i.e. some product residues, it can help to….
Risk Based Limits and Pharmaceutical Cleaning
Q. We are moving from LD50 data to ADE (PDE) limits based on HBELs. This is allowing us to eliminate disposables for low-risk products. How do I know which can be manually cleaned and which needs to be in a washer? Can manual cleaning be validated?
A. Many pharma and biotech companies have been moving to Health-Based Exposure Limits (HBELs) meaning Acceptable Daily Exposure (ADE) or Permitted Daily Exposure (PDE) limits as detergent residue limits.
Perchlorate Free Detergents
We are looking for a laboratory dishwasher detergent that does not contain perchlorates. One of our end users analyzes for trace levels of perchlorates, so we cannot have a detergent that has that type of impurities.
Detecting Residue in Cleaning Validation
When beginning cleaning validation, a company must identify the residues to be tested and then select the best detection method. Alconox Inc. is here to help. We provide validation service support