Pharmaceutical

Q: We are starting a new bioprocessing facility where we will be cleaning stainless steel tanks via a Clean-In-Place sprayball system? How do I approximate how much detergent I will need? We are considering Alcojet or Solujet, follow by an acidic rinse with Citrajet. Is this a good plan? Any advice? A: A good rule of thumb for tis you need about….

Q:  What is the difference between Liquinox vs. Citranox?  We are using Liquinox for many of our applications but are having trouble with stainless steel cleaning cannulas with a small ID.  Is Citranox the answer if the residue is inorganic?

A: Although Liquinox detergent is excellent at cleaning a host of residues, Citranox cleaner is indeed the better choice if we are fairly certain this is a largely inorganic residue.

Q. How do you calculate the swab limit, once it has been extracted in solution?
A. In general the swab limit for cleaning validations calculations go as follows:

Q: What can you recommend for cleaning glassware used in a compounding pharmacy?

A: For cleaning related to general compounding pharmacy residues via a washer, we would look to the same low foaming detergents used in pharmaceutical CIP systems as laid out here: 

Q: For ease of use, we would like to use the concentrated detergent in our lab directly, then add water.  Any issues with that?

A:  For Alconox Inc. manufactured detergents intended for manual / clean out of place use, we recommend making prior dilutions for usage of the detergents with known concentrations. However, an alternative would be to add a small amount of detergent concentrate (powder or liquid)….